![]() Further studies are needed to find which methods of anticoagulation is optimal in patients with COVID-19 infection with AKI requiring CRRT. Conclusions: We found that COVID-19 patients with AKI requiring CRRT had similar CRRT hemofilter half-life compared with sepsis-associated AKI patients with use of regional citrate anticoagulation and systemic heparin use. Thesubcuta-neous half-life of low molecular weight heparin is about 4 hours, measured as anti-Xa activity. However, However, significantly more patients with COVID-19 were on systemic heparin compared to the non-COVID-19 patients (69% vs 13%, p= 0.02) ( fig. The half-life of unfractionated heparin is dose-dependentbut at normal intravenous doses is from 45-60 minutesbybothassaymethods. The number of CRRT hemofilter changes per day were also similar in both groups (0.6 filter changes per day, p=0.84) ( fig. The mean half-life of CRRT hemofilter was similar in COVID-19 patients compared to non-COVID-19 patients (27.4 hours vs 27.5 hours, p=0.79). Results: A total of 27 ICU patients with AKI requiring CRRT were included in the study, 13 with COVID-19 infection and 14 with septic shock. Analyses were performed on Microsoft Excel and MedCalc. Time to event data was analyzed with Kaplan-Meier curves. We used independent t-test and chi square test to determine statistical significance of CRRT filter clotting and related factors in COVID-19 patients compared with septic shock patients in the ICU. ![]() Methods: Retrospective single center study of adult patients with COVID-19 infection compared to those with septic shock admitted to the ICU at a tertiary university hospital April-October 2020. ABSTRACT Background: The aim of our study is to compare clotting of CRRT filters in patients with COVID-19-associated AKI vs.
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